Cyclic acyl amidines as unexpected C4-donors for fully substituted pyridine ring formation in the base mediated reaction with malononitrile
作者： Volodymyr Tkachuk , Vladyslava Merkulova , Iryna Omelchenko , Axelle Arrault , Olga Hordiyenko
DOI: 10.1016/J.TETLET.2019.06.038
关键词:
摘要: Abstract A new one-step, pseudo four-component approach for the synthesis of fully substituted pyridines via ring-opening cyclic acyl amidine 3-amino-1H-isoindol-1-one and its aza-analogues during reaction with malononitrile in presence sodium methoxide, followed by pyridine ring closure is reported. This method allows one-step preparation previously unknown 2-(pyridin-4-yl)(hetero)aryl carboxamides good yields under mild conditions.
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