IgG opsonization of merozoites: multiple immune mechanisms for malaria vaccine development.

摘要: Global eradication of the human-infecting malaria parasite Plasmodium falciparum, major cause mortality, is unlikely to be achieved without an effective vaccine. However, our limited understanding how protective immune responses target parasites in humans, and best elicit these through vaccination, has hampered vaccine development. The red blood cell invading stage lifecycle (merozoite) displays antigens that are attractive candidates as they accessible antibodies raise high antibody titres naturally individuals. number merozoite response, their structural functional diversity, led a large lead being pursued candidates. Despite seemingly spoilt for choice terms candidates, there still lack consensus on exactly reduce parasitemia disease. In this review we describe various mechanisms can result from IgG opsonization merozoites, highlight recent developments support role acquired vaccine-induced immunity.