Bile acid transport across the hepatocyte canalicular membrane.

摘要: Transport of bile acids across the canalicular membrane hepatocyte provides primary motive force for generation flow and is rate limiting in vectorial movement from blood to bile. Several distinct carriers have been defined based on physiological studies isolated hepatocytes, vesicles, couples, perfused rat liver including potential-driven ATP-dependent mechanisms. groups functionally reconstituted a acid transport protein M(r) approximately 110 kDa. The mechanism secretion monovalent appears be mediated by yet identified ATP binding cassette family transporters. However, it remains conjectural whether components are one or more proteins. Bile sulfates glucuronides substrates canali...