Thyroid transcription factor-1, but not p53, is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid

摘要: Moderately differentiated neuroendocrine carcinoma/atypical carcinoid tumor is the most common nonsquamous malignancy in larynx; however, due to morphologic overlap and calcitonin immunoreactivity, it can be difficult distinguish from thyroid medullary carcinoma. Currently, low serum reliable means for distinguishing primary laryngeal moderately carcinoma metastatic Thyroid transcription factor-1 (TTF-1) positive at least 80% of carcinomas, but has not been evaluated carcinomas. Additionally, suggested that p53 carcinomas negative other tumors, this validated. The purpose study was determine if immunohistochemical markers TTF-1 could used discriminate between Eight 10 were identified archival files BWH MGH Pathology Departments. Hematoxylin eosin slides reviewed, immunohistochemistry performed using antibodies calcitonin, TTF-1, p53. Calcitonin demonstrated immunoreactivity 100% (N=8) (N=10). There weak, focal with one eight (13%) whereas nine ten (90%) strong diffuse staining seven these cases (78%). three six (50%) (30%) Our data demonstrate or p53, may helpful In particular, and/or favors a diagnosis over