Mechanical matching nanofibrous vascular scaffold with effective anticoagulation for vascular tissue engineering

摘要: Abstract As a vascular scaffold, it should have proper mechanical property to match autologous tissue and resist the blood pressure. The development of biomimetic surface with biomolecules which is able mimic anticoagulation properties fundamental difficult in research for vessel substitutes overcome formation thrombi. In present research, heparin-grafted poly(ester-urethane)urea/gelatin (PU75-E/N-Hep) nanofibrous tubular scaffold was prepared via electrospinning technique followed by heparin grafting. fabricated PU75-E/N-Hep showed higher hydrophilicity, matched improved compatibility. Furthermore, cell viability, morphology from cells culture vitro H&E staining, Masson's trichrome immunohistochemistry immunofluorescent staining were proceeded after implanted rat's abdominal arterues 1 week 4 weeks, demonstrating that contributed facilitating migration growth smooth muscle as well inducing rapid adhesion endothelial cells. Hence, promising candidate can not only prevent acute thrombosis but also promote regeneration tissue.