Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome (IRIS)

摘要: Progressive multifocal leukoencephalopathy is a viral encephalitis induced by the John Cunningham (JC) virus, an ubiquitous neurotropic papovavirus of genus polyomavirus that in healthy people latency resides kidney and bone marrow cells. Activation entry into CNS were first seen patients with malignancies hematopoietic system impaired immune system. During 1980 1990s appearance human immunodeficiency virus infection humans, PML was found to be most important opportunistic central nervous As result highly efficient immunosuppressive immunomodulatory treatments, recent years, number cases again increased. prevented intact cellular response accordingly reconstitution can terminate established disease CNS. However, forced lead massive destruction virus-infected This may clinical exacerbation associated high morbidity mortality referred as inflammatory syndrome (PML-IRIS). In present review, we discuss virological properties routes CNS, but mostly focus on pathology PML-IRIS role these disorders. We show from predominant JC oligodendrocytes and, lesser extent, infected neurons. Inflammation encephalitides seems driven dominant cytotoxic T cell which massively exaggerated during IRIS.