A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection.

摘要: Pancreatic cancer is a leading cause of cancer-related deaths in the western world. Patients with pancreatic have poor prognosis, partly due to difficulties detecting it at early stages. While different markers been associated cancer, many them show suboptimal sensitivity and specificity. Serum autoantibodies against tumor-associated antigens recently emerged as stage biomarkers for types cancers. Given urgent need reliable we undertook systematic review published literature identify primary articles that evaluated serum detection by searching PubMed ISI Web Knowledge. Two reviewers extracted data on study characteristics results independently. Overall, 31 studies evaluating 124 individual met inclusion criteria. In general, single autoantibody showed relatively low sensitivities high A combination markers, either multiple or combined led better diagnostic performance. However, most analyzed only reported therefore be independently validated. We conclude might present an option but more work needed validate signatures are cancer.