Immunodepression after major surgery in normal patients.

摘要: Multiple parameters of in vivo and vitro immune function were measured serially before, during, following nephrectomy 12 normal renal transplant donors. All functions studied (total blood lymphocyte count, B-cell T-cell mitogen blastogenic response, mixed leukocyte reactivity as both responder stimulator) decreased on induction anethesia continued to fall during after operation reach a low point the evening nephrectomy. Depth depression rate recovery varied with individual function, but all near by fifth postoperative day. The delayed hypersensitivity response cutaneously administered recall antigens declined more gradually was still falling at Return preoperative skin delayed, being complete for streptokinase/streptodornase (SK/SD) 10 14 days incomplete long 2 3 weeks mumps Candida antigens. Serum immunoglobulins did not change. These findings suggest correlation among responses commonly used assays cellular immunity poor tests. Although surgery anesthesia results measurable clinically significant problems arise these patients.