ROLES OF GI AND GQ/11 IN MEDIATING DESENSITIZATION OF THE LUTEINIZING HORMONE/CHORIOGONADOTROPIN RECEPTOR IN PORCINE OVARIAN FOLLICULAR MEMBRANES

摘要: Although desensitization of most guanine nucleotide-binding (G) protein receptors is triggered by phosphorylation the receptor, LH/CG receptor (-R) in porcine follicular ovarian membranes appears to be independent LH/CG-R phosphorylation. We therefore evaluated whether reflected a direct inhibition adenylyl cyclase (AC) activity either theα -subunit Gi or βγ-subunits derived from any membrane G proteins activated response activation competition between Gs and that phospholipase C for binding sites on LH/CG-R. The results showed AC was not inhibited upon despite evidence ACs membranes, when maximally forskolin, could were guanyl-5′-yl imidodiphosphate, pertussis toxin pretreatment raised ...