A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma.

摘要: The proto-oncogene c-erbB-2 is overexpressed in 25-30% of breast cancers through increased transcription and amplification the gene, We have previously described a factor, OB2-1 which upregulates closely related to developmentally regulated AP-2. Further analysis affinity purified has now shown that it fact combination proteins from three AP-2-related genes, AP-2 alpha gene two new human family members, beta gamma whose cloning characterisation are here. All show high degree homology capable binding promoter as homo- or heterodimers. can also activate reporter construct, but 3-4 times more active this regard than beta. In addition both expressed at elevated levels majority overexpressing mammary tumour lines examined. Mechanisms may led these cells discussed.