MT-2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection.

摘要: The ability of human immunodeficiency virus type 1 (HIV-1) isolates to replicate in MT-2 cells was investigated as a prognostic marker for disease progression and CD4+ lymphocyte depletion 53 HIV-1-infected, asymptomatic individuals. MT-2-negative viruses were isolated from 49% the patients both early late during follow-up period; 38% converted being negative positive, while 11% positive throughout study. One individual showed fluctuating phenotype. loss lymphocytes significantly more rapid MT-2-positive patients. We found broad spectrum changes whose changed its tropism. Our data suggest that could be divided into three general patterns. A stable or slowly decreasing count fall 44% patients, no significant change rate decline noted level after tropism 12% correlation between clinical symptoms also noted. Half with study still mean time 80 months, only 15% those who remained asymptomatic. All at inclusion developed HIV-1-related symptoms, half them died status 16 determined AIDS diagnosis; 50% Mt-2 negative. No difference AIDS-defining diagnoses counts diagnosis Knowledge HIV-1 phenotype may improve recognition progressive disease.