4-Hydroxy-3-methoxy-benzaldehyde series aroyl hydrazones: synthesis, thermostability and antimicrobial activities
作者： Liang Wang , Da-Gang Guo , Yan-Yan Wang , Chang-Zheng Zheng
DOI: 10.1039/C4RA11747F
关键词:
摘要: Efficient synthetic procedures for the preparation of aroyl hydrazones were developed by converting corresponding ethyl ester into hydrazides, followed a reaction with 4-hydroxy-3-methoxy-benzaldehyde. A series aromatic hydrazides and characterized elemental analysis, IR, 1H NMR, 13C NMR thermogravimetric analysis. The thermal gravity analysis showed that compounds 3a–3d stable below 228.23, 227.65, 118.97 179.51 °C, respectively. antimicrobial activity towards Staplylococcus aureus, Escherichia coli Pseudomonas aeruginosa. antibacterial experiments indicated had higher than hydrazides. presence hydroxyl group, as well number position groups, important further enhance activity.
rsc.org
sci-hub.se 参考文章(23)
Emmanuel N. Nfor, Ahmad Husian, Felicite Majoumo-Mbe, Innocent N. Njah, Offiong E. Offiong, Susan A. Bourne, Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride Polyhedron. ,vol. 63, pp. 207- 213 ,(2013) , 10.1016/J.POLY.2013.07.028
Anu Kajal, Suman Bala, Sunil Kamboj, Vipin Saini, Synthesis, characterization, and computational studies on phthalic anhydride-based benzylidene-hydrazide derivatives as novel, potential anti-inflammatory agents Medicinal Chemistry Research. ,vol. 23, pp. 2676- 2689 ,(2014) , 10.1007/S00044-013-0848-1
R. Kalsi, K. Pande, T.N. Bhalla, J.P. Barthwal, G.P. Gupta, S.S. Parmar, Anti-Inflammatory Activity of Quinazolinoformazans Journal of Pharmaceutical Sciences. ,vol. 79, pp. 317- 320 ,(1990) , 10.1002/JPS.2600790409
Carla Sousa, Cristina Freire, Baltazar De Castro, Synthesis and Characterization of Benzo-15-Crown-5 Ethers with Appended N2O Schiff Bases Molecules. ,vol. 8, pp. 894- 900 ,(2003) , 10.3390/81200894
Neslihan Özbek, Saliha Alyar, Nurcan Karacan, Experimental and theoretical studies on methanesulfonic acid 1-methylhydrazide: Antimicrobial activities of its sulfonyl hydrazone derivatives Journal of Molecular Structure. ,vol. 938, pp. 48- 53 ,(2009) , 10.1016/J.MOLSTRUC.2009.09.002
Mehmet Sönmez, Hatice Gamze Sogukomerogullari, Feyza Öztemel, İsmet Berber, Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes Medicinal Chemistry Research. ,vol. 23, pp. 3451- 3457 ,(2014) , 10.1007/S00044-014-0925-0
Koçyiğit-Kaymakçıoğlu Bedia, Oruç Elçin, Unsalan Seda, Kandemirli Fatma, Shvets Nathaly, Rollas Sevim, Anatholy Dimoglo, None, Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity. European Journal of Medicinal Chemistry. ,vol. 41, pp. 1253- 1261 ,(2006) , 10.1016/J.EJMECH.2006.06.009
H. Güzin Aslan, Nurcan Karacan, Aromatic sulfonyl hydrazides and sulfonyl hydrazones: antimicrobial activity and physical properties Medicinal Chemistry Research. ,vol. 22, pp. 1330- 1338 ,(2013) , 10.1007/S00044-012-0104-0
Surendra S Parmar, AK Gupta, TK Gupta, Virgil I Stenberg, None, Synthesis of substituted benzylidinohydrazines and their monoamine oxidase inhibitory and anticonvulsant properties. Journal of Pharmaceutical Sciences. ,vol. 64, pp. 154- 157 ,(1975) , 10.1002/JPS.2600640136
R.N. Singh, Amit Kumar, Poonam Rawat, Anchal Srivastsva, Synthesis, spectroscopic and structural evaluation of ethyl 2-cyano-3-{5-[(4-nitro-benzoyl)-hydrazonomethyl]-1H-pyrrol-2-yl}-acrylate using experimental and theoretical approaches Journal of Molecular Structure. ,vol. 1049, pp. 419- 428 ,(2013) , 10.1016/J.MOLSTRUC.2013.07.001