The impact of hepatitis B viral load on recurrence after complete necrosis in patients with hepatocellular carcinoma who receive transarterial chemolipiodolization

摘要: BACKGROUND. Hepatocellular carcinoma (HCC) has a high tendency for recurrence after radical treatment. Apart from tumor and liver function parameters, little is known about the role of hepatitis B virus (HBV) factors in HCC. The objective this study was to identify potential relation between viral load HCC patients undergoing transarterial chemolipiodolization. METHODS. This cohort 62 consecutive who had HBV-related achieved complete necrosis with chemolipiodolization. Risk factors, including posttreatment recurrence, were analyzed. RESULTS. Overall, 32 (51.6%) developed during period (7.2–37.5 months). Multivariate analysis established Child-Pugh Class (P = .014), multiple tumors .013), (HBV DNA levels >105 copies/mL) at .001) as independent risk recurrence. On both univariate multivariate analyses, time identified strongest factor recurrence; moreover, its statistically significant effects still observed even when conducting analyses separately local .018) distant .009). CONCLUSIONS. Among individuals underwent chemolipiodolization, HBV among most important irrespective locational pattern current findings underscored need future work that tests applicability antiviral therapy reduce setting. Cancer 2007. © 2007 American Society.