Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways

摘要: Addiction to psychostimulant methamphetamine (METH) remains a major public health problem in the world. Animal models that use METH self-administration incorporate many features of human drug-taking behavior and are very helpful elucidating mechanisms underlying addiction. These also helping decipher neurobiological substrates associated neuropsychiatric complications. This review summarizes our work on influence dopamine systems, transcription immune responses brain. We used rat model with extended access (15 h/day for eight consecutive days) investigate effects voluntary intake markers system integrity changes gene expression observed brain at 2 h–1 month after cessation drug exposure. Extended caused consistent clinical findings reported neuroimaging postmortem studies addicts. In addition, using striatal tissues from self-administering rats revealed increased genes involved cAMP response element binding protein (CREB) signaling pathway activation neuroinflammatory data show an association exposure neuroplastic cascades The may be promoting Neuroinflammatory processes striatum underlie cognitive deficits, depression, parkinsonism Therapeutic approaches include suppression neuroinflammation beneficial addicted patients.