Aspects of fatigue in post-polio

摘要: Fatigue is a subjectively experienced and complex phenomenon one of the most common symptoms post-polio syndrome (PPS) occurring in up to 90% patients. Experiencing fatigue, negatively affects work performance, family life, social relationships, quality life (QOL). can originate central or peripheral nervous system be various ways, for example as general, physical, mental, muscle fatigue. The overall aim thesis was evaluate analyse fatigue PPS specific aims were follows: determine whether generally fatigued patients display cognitive deficits compared with non-fatigued subjects; vitality relative effects physiological psychological parameters on level; characterize patients, define subgroups across continuum; finally, describe QOL characteristics measured using SF-36 instrument responders non-responders after intravenous immunoglobulin treatment (IVIG). research examines three samples Study I include twenty without general recruited from out-patient clinic at Huddinge University Hospital, Stockholm. Studies II III baseline data 143 Swedish multicenter study, IV based follow-up 112 Danderyd Stockholm, before IVIG treatment. No performance differences could detected between nonfatigued systematically varying test order did not cause significant mental Vitality mostly dependent rather than parameters, prominent predictor. Contrary expectations, increased while pain decreased increasing age. Fatigued characterized by significantly lower age, more physical problems Furthermore, group, relatively important In total sample scores subdomains Vitality, Bodily pain, Social function, Role-emotional Mental compound score (MCS) improved six-month follow-up. identified possible outcome variables positive-, non, negative identified. Positive low i.e., high It concluded that, PPS, nature – being that does affect cognition. whom considered subgroup, may respond positively levels are ones who benefit