Prereproductive stress in adolescent female rats affects behavior and corticosterone levels in second-generation offspring.

摘要: Summary Human and animal studies indicate that vulnerability to stress may be heritable. We have previously shown chronic, mild prereproductive (PRS) in adolescent female rats affects behavior corticotropin releasing factor 1 (CRF1) expression the brain of first-generation (F1) offspring. Here, we investigated effects PRS on anxiogenic CRF1 male second-generation (F2) Furthermore, assessed levels hormone corticosterone (CORT), a direct marker hypothalamic–pituitary–adrenal (HPA) axis function, females their F1 F2 progeny. offspring demonstrated decreased mRNA at birth, alterations adulthood. CORT were elevated female, but not male, In F2, also varied sex-dependent manner. These findings leads behavioral extend offspring, has transgenerational endocrine function. Together with our previous findings, these data HPA function across three generations, highlight importance examining both