Physiological and Proteomic Approaches to Understanding Human Sperm Function

作者: Sarah J. Conner , Linda Lefièvre , Jackson Kirkman-Brown , Gisela S. M. Machado-Oliveira , Frank Michelangeli

DOI: 10.1007/978-1-59745-176-5_5

关键词:

摘要: Sperm dysfunction is the single most common defined cause of infertility. Approximately 1 in 15 men are subfertile and condition increasing frequency. However, diagnosis poor and, excluding assisted conception, there no treatment because our limited understanding cellular, biochemical, molecular functioning spermatozoon. The underlying premise research program to establish a rudimentary processes necessary for successful fertilization. We detail advances calcium signaling cell outline genetic proteomic technologies that being used improve condition.

参考文章(126)
Mathew J. Tomlinson, Christopher L. R. Barratt, Efrossini Kessopoulou, The diagnostic and prognostic value of traditional semen parameters. Journal of Andrology. ,vol. 20, pp. 588- 593 ,(1999) , 10.1002/J.1939-4640.1999.TB02559.X
M Wictome, I Henderson, A G Lee, J M East, Mechanism of inhibition of the calcium pump of sarcoplasmic reticulum by thapsigargin. Biochemical Journal. ,vol. 283, pp. 525- 529 ,(1992) , 10.1042/BJ2830525
G S M Machado-Oliveira, I A Brewis, K L Pixton, S J Publicover, F Michelangeli, L Lefièvre, S J Conner, J Kirkman-Brown, C L R Barratt, C Jimenez-Gonzalez, Understanding the physiology of pre-fertilisation events in the human spermatozoa--a necessary prerequisite to developing rational therapy. Society of Reproduction and Fertility supplement. ,vol. 63, pp. 237- 255 ,(2007)
Lars Björndahl, Majid Mohammadieh, Mohammad Pourian, Inger Söderlund, Ulrik Kvist, Contamination by Seminal Plasma Factors During Sperm Selection Journal of Andrology. ,vol. 26, pp. 170- 173 ,(2005) , 10.1002/J.1939-4640.2005.TB01080.X
Charles H. Muller, Rationale, interpretation, validation, and uses of sperm function tests. Journal of Andrology. ,vol. 21, pp. 10- 30 ,(2000) , 10.1002/J.1939-4640.2000.TB03270.X
T Baba, S Azuma, S Kashiwabara, Y Toyoda, Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization. Journal of Biological Chemistry. ,vol. 269, pp. 31845- 31849 ,(1994) , 10.1016/S0021-9258(18)31772-1
P F Blackmore, S J Beebe, D R Danforth, N Alexander, Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm. Journal of Biological Chemistry. ,vol. 265, pp. 1376- 1380 ,(1990) , 10.1016/S0021-9258(19)40024-0
Lars Björndahl, Christopher L. R. Barratt, Semen analysis: setting standards for the measurement of sperm numbers. Journal of Andrology. ,vol. 26, pp. 11- 11 ,(2005) , 10.1002/J.1939-4640.2005.TB02864.X
Michael J. Berridge, Peter Lipp, Martin D. Bootman, The versatility and universality of calcium signalling Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 11- 21 ,(2000) , 10.1038/35036035
Elisabetta Baldi, Rosaria Casano, Costanza Falsetti, Csilla Krausz, Mario Maggi, Gianni Forti, None, Intracellular Calcium Accumulation and Responsiveness to Progesterone in Capacitating Human Spermatozoa Journal of Andrology. ,vol. 12, pp. 323- 330 ,(1991) , 10.1002/J.1939-4640.1991.TB01610.X