Modification of Kagan's amide for improved activity as Chiral Solvating Agent in enantiodiscrimination during NMR analysis
作者： Nilesh Jain , Aditya N. Khanvilkar , Sibaprasad Sahoo , Ashutosh V. Bedekar
DOI: 10.1016/J.TET.2017.11.036
关键词:
摘要: Abstract A modification is proposed in Kagan's amide order to improve its ability offer stronger hydrogen bonding and hence better bind with substrates. Introduction of chlorine the aromatic ring along two nitro groups, increases acidic character makes bond stronger, concept tested by making three derivatives effect confirmed nmr analysis. The modified chlorinated amides were then as chiral solvating agents for detection optical purity several types substrates where supramolecular recognition measured situ Several guest molecules such amide, sulfoxide, epoxy-keto, hydroxy acid, diacid phosphoric acid scanned this study efficiency further established comparison samples known purity.
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