Effect of Human Leukocyte Interferon on Hepatitis B Virus Infection in Patients with Chronic Active Hepatitis

摘要: Abstract Four patients with chronic hepatitis B infection and active were treated human leukocyte interferon. Three of them had consistently elevated levels circulating Dane-particle markers, including Dane-particle-associated DNA polymerase activity, core antigen DNA. Parenteral interferon administration at a dosage between 6.0 X 103 17 x 104 U per kilogram day was associated rapid reproducible fall in all markers the three patients. The suppressive effect transient when given for 10 days or less but appeared to be more permanent prolonged month more. In addition, long-term therapy marked surface two disappearance e Interferon may useful limiting carrier infectivity eradicating infection. (N Engl J Med 295:517–...