Acidic FGF induces NGF and its mRNA in the injured neocortex of adult animals.
作者： Bonald C. Figueiredo , Katharina Plüss , Malgorzata Skup , Uwe Otten , A. Claudio Cuello
DOI: 10.1016/0169-328X(95)00099-E
关键词:
摘要: Recently we reported that human recombinant acidic fibroblast growth factor (aFGF) is capable of preventing degeneration nucleus basalis magnocellularis neurons in vivo and inducing astrocytes vitro. In the present study, effects aFGF on concentration nerve (NGF) its messenger RNA were investigated rat cerebral cortex following unilateral cortical infarction. Lesioned animals exhibited a significant increase NGF remaining ipsilateral to lesion. After combining lesion with intracerebroventricular application (12 μg/day for 7 days), observed an 8-fold marked level steady state mRNA relative controls ipsilaterally, less pronounced effect contralateral cortex. These results support hypothesis neurotrophic previously shown basic FGF (bFGF) neurotrophin-sensitive mediated by increased production within injured central nervous system (CNS) adult animals.
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sci-hub.se 参考文章(50)
A. Claudio Cuello, Chapter 32: Trophic responses of forebrain cholinergic neurons: a discussion Progress in Brain Research. ,vol. 98, pp. 265- 277 ,(1993) , 10.1016/S0079-6123(08)62408-5
CA Altar, M Dugich-Djordjevic, M Armanini, C Bakhit, Medial-to-lateral gradient of neostriatal NGF receptors: relationship to cholinergic neurons and NGF-like immunoreactivity. The Journal of Neuroscience. ,vol. 11, pp. 828- 836 ,(1991) , 10.1523/JNEUROSCI.11-03-00828.1991
F Gomez-Pinilla, JW Lee, CW Cotman, Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection The Journal of Neuroscience. ,vol. 12, pp. 345- 355 ,(1992) , 10.1523/JNEUROSCI.12-01-00345.1992
C. A. Dionne, G. Crumley, F. Bellot, J. M. Kaplow, G. Searfoss, M. Ruta, W. H. Burgess, M. Jaye, J. Schlessinger, Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. The EMBO Journal. ,vol. 9, pp. 2685- 2692 ,(1990) , 10.1002/J.1460-2075.1990.TB07454.X
PM Richardson, VM Issa, RJ Riopelle, None, Distribution of neuronal receptors for nerve growth factor in the rat The Journal of Neuroscience. ,vol. 6, pp. 2312- 2321 ,(1986) , 10.1523/JNEUROSCI.06-08-02312.1986
A Stock, K Kuzis, WR Woodward, R Nishi, FP Eckenstein, Localization of acidic fibroblast growth factor in specific subcortical neuronal populations The Journal of Neuroscience. ,vol. 12, pp. 4688- 4700 ,(1992) , 10.1523/JNEUROSCI.12-12-04688.1992
Claudio Basilico, David Moscatelli, The FGF family of growth factors and oncogenes. Advances in Cancer Research. ,vol. 59, pp. 115- 165 ,(1992) , 10.1016/S0065-230X(08)60305-X
FP Eckenstein, GD Shipley, R Nishi, Acidic and basic fibroblast growth factors in the nervous system: distribution and differential alteration of levels after injury of central versus peripheral nerve The Journal of Neuroscience. ,vol. 11, pp. 412- 419 ,(1991) , 10.1523/JNEUROSCI.11-02-00412.1991
Hidemasa Kato, Akio Wanaka, Masaya Tohyama, Co-localization of basic fobroblast growth factor-like immunoreactivity and its receptor mRNA in the rat spinal cord and the dorsal root ganglion Brain Research. ,vol. 576, pp. 351- 354 ,(1992) , 10.1016/0006-8993(92)90704-D
J.Leach Scully, U. Otten, Glucocorticoid modulation of neurotrophin expression in immortalized mouse hippocampal neurons. Neuroscience Letters. ,vol. 155, pp. 11- 14 ,(1993) , 10.1016/0304-3940(93)90662-5