Selecting the dose metric in reverse dosimetry based QIVIVE

G. Klatskin, J. P. Nolan, R. L. Scheig, Delayed hepatitis and cirrhosis in weanling rats following a single small dose of the senecio alkaloid, lasiocarpine. American Journal of Pathology. ,vol. 49, pp. 129- 151 ,(1966)

Jochem Louisse, Sieto Bosgra, Bas J. Blaauboer, Ivonne M. C. M. Rietjens, Miriam Verwei, Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling Archives of Toxicology. ,vol. 89, pp. 1135- 1148 ,(2015) , 10.1007/S00204-014-1289-4

Floris A. Groothuis, Minne B. Heringa, Beate Nicol, Joop L.M. Hermens, Bas. J. Blaauboer, Nynke I. Kramer, Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations Toxicology. ,vol. 332, pp. 30- 40 ,(2015) , 10.1016/J.TOX.2013.08.012

Jochem Louisse, Esther de Jong, Johannes J. M. van de Sandt, Bas J. Blaauboer, Ruud A. Woutersen, Aldert H. Piersma, Ivonne M. C. M. Rietjens, Miriam Verwei, The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man Toxicological Sciences. ,vol. 118, pp. 470- 484 ,(2010) , 10.1093/TOXSCI/KFQ270

Marije Strikwold, Bert Spenkelink, Ruud A. Woutersen, Ivonne M. C. M. Rietjens, Ans Punt, Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human Archives of Toxicology. ,vol. 87, pp. 1709- 1723 ,(2013) , 10.1007/S00204-013-1107-4

Rozaini Abdullah, Wasma Alhusainy, Jasper Woutersen, Ivonne M.C.M. Rietjens, Ans Punt, Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I Food and Chemical Toxicology. ,vol. 92, pp. 104- 116 ,(2016) , 10.1016/J.FCT.2016.03.017

H. Mielke, E. Di Consiglio, R. Kreutz, F. Partosch, E. Testai, U. Gundert-Remy, The importance of protein binding for the in vitro-in vivo extrapolation (IVIVE)-example of ibuprofen, a highly protein-bound substance. Archives of Toxicology. ,vol. 91, pp. 1663- 1670 ,(2017) , 10.1007/S00204-016-1863-Z

Marije Strikwold, Bert Spenkelink, Laura H. J. de Haan, Ruud A. Woutersen, Ans Punt, Ivonne M. C. M. Rietjens, Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols Archives of Toxicology. ,vol. 91, pp. 2119- 2133 ,(2017) , 10.1007/S00204-016-1881-X

Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M. C. M. Rietjens, Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans. Molecular Nutrition & Food Research. ,vol. 61, pp. 1600894- ,(2017) , 10.1002/MNFR.201600894

Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M C M Rietjens, In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans. British Journal of Pharmacology. ,vol. 174, pp. 2739- 2757 ,(2017) , 10.1111/BPH.13900