Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate.

摘要: The metabolic and toxic effects of 2-chloropropionate dichloroacetate, activators the pyruvate dehydrogenase complex, were compared. In 4-hr fasted mice, oral LD50 values for dichloroacetate 15.4 +/- 0.1 32.1 1.1 mmol/kg, respectively. suckling rats, both compounds effectively lowered blood lactate glucose levels increased ketone bodies. Although comparable brought about by on other metabolites, caused a greater increase in prolonged toxicity study using male decreased growth rate food consumption neurotoxic effects. Both hind limb weakness, slower nerve conduction velocities diameter tibial nerves. 2-Chloropropionate treatment testicular abnormalities manifested maturation arrest degeneration germ cells. 2-Chloropropionate-treated rats had significantly lower plasma triacylglycerol than control or dichloroacetate-treated rats. mature total serum bodies but not elevated 2-chloropropionate. may lack sufficient safety to warrant chronic use humans, it is useful research tool studying activation complex. Since converted oxalate as ketogenic be clinically situations requiring only short-term therapy.