Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer Registry

摘要: Studies of the histopathology ovarian cancer arising in patients with germline mutations BRCA1 or BRCA2 have shown inconsistent findings. We analyzed large number tumors from women enrolled Gilda Radner Familial Ovarian Cancer Registry for correlations between and BRCA mutation status. Histopathology slides reports were reviewed histology, grade, stage cancers ovary peritoneum 220 126 families. At least one affected member each family was genes, mutation-positive families compared those mutation-negative Of 70 38 BRCA1-positive families, 69 had epithelial carcinoma a dysgerminoma. Fifteen 16 nine BRCA2-positive cancer, primary peritoneal cancer. 134 79 BRCA-negative 118 carcinoma, 11 borderline tumors, three nonepithelial two carcinoma. There fewer grade 1 (p < 0.001) I = 0.005) BRCA-positive than Neither mucinous nor found In conclusion, are more likely to be high-grade extraovarian spread Borderline do not appear part phenotype genes.