Tamoxifen and ocular toxicity.

摘要: Tamoxifen, widely used in the management of breast cancer, has been associated with a reduction mortality and recurrence as well occurrence controlateral tumors. It is generally tolerated, apart from certain well-documented adverse effects concerning mainly reproductive organs, most worrying being its carcinogenicity for endometrium. Ocular toxicity also reported one possible complication drug, lesions described retina, cornea, or optic nerve, especially women treated high daily cumulated doses tamoxifen, although some cases have standard doses. The incidence such ocular complications rather low considering large number patients receiving tamoxifen. reversibility these lesions, if discovered time, emphasizes need clinicians to be aware reactions raises question periodic ophthalmological screening examinations among