Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat – a type 1 diabetes mellitus model

摘要: Abstract Ethnopharmacological relevance The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential complications. Aim study We investigated neuroprotective a suspension G. seeds long-term rat model. Materials methods Wistar rats, made diabetic single injection streptozotocin were monitored for 8 months. Then, they administered distilled water or oral aqueous daily 30 days. Body weight glycemia determined before after treatment. After sacrifice, cerebella dissected out processed stereological quantification Purkinje cells. Histopathological immunohistochemical analyses markers neuroinflammation neurodegeneration performed. Results cell counts significantly increased, histopathological signs apoptosis decreased, animals treated compared rats given water. Glycemia was also markedly improved body restored non-diabetic values, following Conclusions These results suggest that treatment general condition protected cells partly improving systemic mitigating neuroinflammation.