The first case of alloantibody against human platelet antigen-15b in Japan: possible alloimmunization by a hydatidiform mole.

摘要: BACKGROUND: The involvement of the human platelet antigen (HPA)-15 system in neonatal alloimmune thrombocytopenia (NAIT) has been reported various populations, but not Japanese population. In Japan, mixed passive hemagglutination assay (MPHA) is used for detection HPA alloantibodies. However, most cases HPA-15 incompatibility are based on monoclonal antibody immobilization (MAIPA) or immunoprecipitation; thus there a possibility that alloantibodies efficiently detected by MPHA, and currently, causative detectable approximately half suspected NAIT Japan. STUDY DESIGN AND METHODS: We examined sera mothers from cases, previously with undetected antibodies using MAIPA technique. Sera 90 were tested presence anti-HPA-15 alloantibodies. RESULTS: Anti-HPA-15b was one case. This case mother first pregnancy diagnosed as hydatid mole–coexisting fetus, baby born NAIT. familial analysis revealed compatibility genotype between (both HPA-15a/a), paternal (HPA-15a/b). mole's tissue genotyped HPA-15b positive. Besides anti-HPA-15b, maternal contain strong HLA Class I antibody CONCLUSIONS: Here we Japan. Alloimmunization against mole seems to be responsible production alloantibody. antibody, however, did apparently involve development newborn, coexisting anti-HLA being possible cause.