Rituximab in treatment-resistant CIDP with antibodies against paranodal proteins.
作者： Luis Querol , Ricard Rojas-García , Jordi Diaz-Manera , Joseba Barcena , Julio Pardo
DOI: 10.1212/NXI.0000000000000149
关键词:
摘要: Objective: To describe the response to rituximab in patients with treatment-resistant chronic inflammatory demyelinating polyneuropathy (CIDP) antibodies against paranodal proteins and correlate autoantibody titers. Methods: Patients CIDP IgG4 anti–contactin-1 (CNTN1) or anti–neurofascin-155 (NF155) who were resistant IV immunoglobulin corticosteroids treated followed prospectively. Immunocytochemistry was used detect anti-CNTN1 anti-NF155 ELISA human recombinant CNTN1 NF155 determine antibody Results: Two had a marked improvement; another patient improved slightly after 10 years of stable, severe disease; fourth an ischemic stroke unrelated treatment lost follow-up. Autoantibodies decreased all treatment. Conclusions: Rituximab is option for anti-CNTN1/NF155 are conventional therapies. Classification evidence: This study provides Class evidence that effective antibodies.
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