Eosinophilic Granulomatosis with Polyangiitis Presented as Acute Polyneuropathy and Cerebral Vasculitis.

摘要: Eosinophilic granulomatosis with polyangiitis (EGPA) is an immune related systemic disease that caused by vasculitis affecting multiple organ systems. It characterized asthma, fever, eosinophilia, cardiac problems, renal injury, and peripheral neuropathy. In this report, we describe a patient EGPA concurrent cerebral infarction acute polyneuropathy mimicking Guillain-Barre syndrome (GBS). A 46-year-old man presented rapidly progressing gait disturbance, muscular weakness, tingling sensation in all four limbs. nerve conduction study revealed sensorimotor limbs, test of the cerebrospinal fluid showed albumin-cytologic dissociation. addition, brain magnetic resonance imaging (MRI) using fluid-attenuated inversion recovery diffusion weighted MRI high signal intensity lesions gadolinium enhancement on T1-weighted right caudate nucleus. After performing laboratory tests, paranasal sinus computed tomography, nasal smear, was diagnosed treated dose glucocorticoid oral cyclophosphamide. conclusion, our findings indicate diagnosis should be considered when presents GBS along unusual symptoms or lesions.