Review and Analysis of Inhalation Dosimetry Methods for Application to Children’s Risk Assessment
作者： Gary L. Ginsberg , Brenda Perkovich Foos , Michael P. Firestone
DOI: 10.1080/15287390590921793
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摘要: Young children have a greater ventilation rate per body weight or pulmonary surface area as compared to adults. The implications of this difference for inhalation dosimetry and children’s risk assessment were evaluated in runs the U.S. Environmental Protection Agency (U.S. EPA) 1994 reference concentration (RfC) methodology ICRP model. Dosimetry estimates made 3-mo-old adults particles Category 1 2 reactive gases following respiratory-tract regions: extrathoracic (ET), tracheobronchial (BB), bronchioles (bb), (PU). Systemic nonreactive (Category 3) gases. Results suggest similar ET all types inhaled materials. BB was also across age groups except that ultrafine region twofold than In contrast, bb generally showed higher pa...
sci-hub.se 参考文章(101)
Ted Martonen, Ira Katz, William Cress, Aerosol deposition as a function of airway disease: cystic fibrosis. Pharmaceutical Research. ,vol. 12, pp. 96- 102 ,(1995) , 10.1023/A:1016294805680
JLCM Dorne, K Walton, AG Renwick, None, Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates. Food and Chemical Toxicology. ,vol. 39, pp. 681- 696 ,(2001) , 10.1016/S0278-6915(01)00005-9
R A Segal, D Hwang, T B Martonen, J D Schroeter, R Burton, M A Dolovich, J S Fleming, C J Musante, R M Spencer, Lung models: strengths and limitations. Respiratory Care. ,vol. 45, pp. 712- 736 ,(2000)
Isabel Vieira, Michelle Sonnier, Thierry Cresteil, Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. FEBS Journal. ,vol. 238, pp. 476- 483 ,(1996) , 10.1111/J.1432-1033.1996.0476Z.X
F J Miller, J D Crapo, B E Barry, Effects of inhalation of 0. 12 and 0. 25 parts per million ozone on the proximal alveolar region of juvenile and adult rats Laboratory Investigation. ,vol. 53, pp. 692- 704 ,(1985)
K. Lisi, D.A. Dixon, E. Friebele, J.J. Konz, Exposure factors handbook ,(1989)
Ling-Yi Chang, Judith A. Graham, Frederick J. Miller, Jean J. Ospital, James D. Crapo, Effects of subchronic inhalation of low concentrations of nitrogen dioxide. I. The proximal alveolar region of juvenile and adult rats. Toxicology and Applied Pharmacology. ,vol. 83, pp. 46- 61 ,(1986) , 10.1016/0041-008X(86)90321-2
J. Valentin, Guide for the Practical Application of the ICRP Human Respiratory Tract Model Annals of the ICRP. ,vol. 32, pp. 13- 14 ,(2002) , 10.1016/S0146-6453(03)00011-3
Gary Ginsberg, Dale Hattis, Abel Russ, Babasaheb Sonawane, Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. Journal of Toxicology and Environmental Health. ,vol. 67, pp. 297- 329 ,(2004) , 10.1080/15287390490273550
Daniel Oscar Rodenstein, Noemi Perlmutter, Dinu Stanescu, Infants are not obligatory nasal breathers. The American review of respiratory disease. ,vol. 131, pp. 343- 347 ,(1985) , 10.1164/ARRD.1985.131.3.343