Effects of Sulfur Dioxide on the Expressions of EGF, EGFR, and COX-2 in Airway of Asthmatic Rats

作者: Ruijin Li , Ziqiang Meng , Jingfang Xie

DOI: 10.1007/S00244-007-9054-9

关键词:

摘要: The pathogenesis of asthma involves a combination genetic and environmental factors. epidemiology studies have shown that SO2 might play an important role in the initiation or exacerbation disease. To investigate asthmatic molecular mechanisms exposed to SO2, male Wistar rats were divided randomly into four equal groups six animals each: (1) group, (2) ovalbumin (OVA) group (asthma group), (3) plus OVA (4) control group. challenged by (5.6 mg/m3) inhalation alone together. mRNA protein levels asthma-related genes (EGF, EGFR, COX-2) analyzed lungs tracheas using real-time reverse transcription–polymerase chain reaction assay, radioimmunoassay method, Western blot analysis, respectively. results showed inhaled increased expressions three tested lung trachea tissues, but only EGFR COX-2 significantly compared with control. However, exposure induced EGF, Meanwhile, enhanced these rat airways, versus alone. These suggested could increase on transcription translation from rats, which be one possible pollution aggravates

参考文章(36)
Tseng Ry, Li Ck, Low level atmospheric sulfur dioxide pollution and childhood asthma. Annals of allergy. ,vol. 65, pp. 379- ,(1990)
H A Boushey, D Sheppard, C F Uehara, J A Nadel, W S Wong, Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. The American review of respiratory disease. ,vol. 122, pp. 873- 878 ,(2015) , 10.1164/ARRD.1980.122.6.873
Robert A. Bethel, Dean Sheppard, Barbara Geffroy, Elizabeth Tam, Jay A. Nadel, Homer A. Boushey, Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects. The American review of respiratory disease. ,vol. 131, pp. 659- 661 ,(1985) , 10.1164/ARRD.1985.131.4.659
Guohua Qin, Ziqiang Meng, Effect of sulfur dioxide inhalation on CYP1A1 and CYP1A2 in rat liver and lung. Toxicology Letters. ,vol. 160, pp. 34- 42 ,(2005) , 10.1016/J.TOXLET.2005.06.002
M. N. HYLKEMA, M. O. HOEKSTRA, M. LUINGE, W. TIMENS, The strength of the OVA‐induced airway inflammation in rats is strain dependent Clinical and Experimental Immunology. ,vol. 129, pp. 390- 396 ,(2002) , 10.1046/J.1365-2249.2002.01938.X
Yuqing Wu, Hong Zhou, Yinyan Xu, Shengnan Li, Enhanced expression of urocortin in lung tissues of rats with allergic asthma Biochemical and Biophysical Research Communications. ,vol. 341, pp. 532- 540 ,(2006) , 10.1016/J.BBRC.2005.12.214
Simon Phipps, Farid Benyahia, Tsan-Teng Ou, Julia Barkans, Douglas S. Robinson, A. Barry Kay, Acute allergen-induced airway remodeling in atopic asthma. American Journal of Respiratory Cell and Molecular Biology. ,vol. 31, pp. 626- 632 ,(2004) , 10.1165/RCMB.2004-0193OC
Sven Ove Hansson, Christina Rudén, Evaluating the risk decision process Toxicology. ,vol. 218, pp. 100- 111 ,(2006) , 10.1016/J.TOX.2005.10.003
I.D. Pavord, A.E. Tattersfield, Bronchoprotective role for endogenous prostaglandin E2 The Lancet. ,vol. 345, pp. 436- 438 ,(1995) , 10.1016/S0140-6736(95)90409-3