作者: Ruijin Li , Ziqiang Meng , Jingfang Xie
DOI: 10.1007/S00244-007-9054-9
关键词:
摘要: The pathogenesis of asthma involves a combination genetic and environmental factors. epidemiology studies have shown that SO2 might play an important role in the initiation or exacerbation disease. To investigate asthmatic molecular mechanisms exposed to SO2, male Wistar rats were divided randomly into four equal groups six animals each: (1) group, (2) ovalbumin (OVA) group (asthma group), (3) plus OVA (4) control group. challenged by (5.6 mg/m3) inhalation alone together. mRNA protein levels asthma-related genes (EGF, EGFR, COX-2) analyzed lungs tracheas using real-time reverse transcription–polymerase chain reaction assay, radioimmunoassay method, Western blot analysis, respectively. results showed inhaled increased expressions three tested lung trachea tissues, but only EGFR COX-2 significantly compared with control. However, exposure induced EGF, Meanwhile, enhanced these rat airways, versus alone. These suggested could increase on transcription translation from rats, which be one possible pollution aggravates