Aluminum Chloride-Mediated Dieckmann Cyclization for the Synthesis of Cyclic 2-Alkyl-1,3-alkanediones: One-Step Synthesis of the Chiloglottones.
作者： Ahlam M. Armaly , Sukanta Bar , Corinna S. Schindler
DOI: 10.1021/ACS.ORGLETT.7B01622
关键词:
摘要: Cyclic 2-alkyl-1,3-alkanediones are ubiquitous structural motifs in many natural products of biological importance. Reported herein is an AlCl3·MeNO2-mediated Dieckmann cyclization reaction general synthetic utility that enables direct access to complex 2-alkyl-1,3-dione building blocks from readily available dicarboxylic acid and chloride substrates. This new strategy the chiloglottone plant pheromones commercial material a single transformation.
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