Role of topical tretinoin in melanoma and dysplastic nevi

摘要: The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They shown to inhibit the proliferation transformed cell lines vitro transplanted tumors vivo. In cultured murine melanoma cells, induce differentiation. Human mixed response. clinical experience with has limited. Previously we activity topical B-all-trans-retinoic acid (Retin-A, vitamin A acid, retinoic tretinoin) against intracutaneous metastases from malignant melanoma. We saw complete remission multiple lesions one individual regression several second patient. This led us conduct present pilot trial tretinoin dysplastic nevus syndrome. latter is precursor some treated benign nevi showing minimal or no dysplasia. Thus appears possess at least its conditions. view these preliminary results, more extensive trials are warranted better define role chemoprevention high-risk lesions.