Pancreatic Cancer Stem Cells in Tumor Progression, Metastasis, Epithelial- Mesenchymal Transition and DNA Repair
作者： Nagaraj S. Nagathihalli , Erika T. Brown
DOI: 10.1007/978-94-007-4590-2_8
关键词:
摘要: Pancreatic cancer is an aggressive solid malignancy with poor response to therapy and the subsequent dismal survival rate has remained a hallmark of this disease. There evidence indicate that pancreatic initiated propagated by stem cell (CSC)s. The CSC population defined its tumor initiating capacity been shown be invasive or metastatic. Loss genome stability DNA repair enzymes aiding in maintenance stability. potential assess risk development lies careful determination one’s nurturing genes are over expressed CSCs both cells turn provide greater damage mechanisms. tumor-initiating as well have large number related repair. RAD51, key player recombinational damaged might act critical mediator efficient mechanisms CSCs. We update here current research results regarding progression, metastasis discuss mechanism
springer.com
elsevier.com
sci-hub.st 参考文章(101)
Amit, S. Adhikari, Metastatic potential of tumor-initiating cells in solid tumors. Frontiers in Bioscience. ,vol. 16, pp. 1927- 1938 ,(2011) , 10.2741/3831
Fazlul H. Sarkar, Dejuan Kong, Yiwei Li, Zhiwei Wang, Pancreatic cancer stem cells and EMT in drug resistance and metastasis Minerva Chirurgica. ,vol. 64, pp. 489- 500 ,(2009)
Christine Richardson, Maria Jasin, Frequent chromosomal translocations induced by DNA double-strand breaks Nature. ,vol. 405, pp. 697- 700 ,(2000) , 10.1038/35015097
Simona Negrini, Vassilis G. Gorgoulis, Thanos D. Halazonetis, Genomic instability — an evolving hallmark of cancer Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 220- 228 ,(2010) , 10.1038/NRM2858
Chenwei Li, C. J. Lee, Diane M. Simeone, Identification of human pancreatic cancer stem cells. Methods of Molecular Biology. ,vol. 568, pp. 161- 173 ,(2009) , 10.1007/978-1-59745-280-9_10
Hiroyuki Takai, Kaoru Tominaga, Noboru Motoyama, Yohji A Minamishima, Hiroyasu Nagahama, Tadasuke Tsukiyama, Kyoji Ikeda, Keiko Nakayama, Makoto Nakanishi, Kei-ichi Nakayama, None, Aberrant cell cycle checkpoint function and early embryonic death in Chk1 −/− mice Genes & Development. ,vol. 14, pp. 1439- 1447 ,(2000) , 10.1101/GAD.14.12.1439
Rosalind A. Segal, Elliot N. DeHaan, Robyn S. Klein, Joshua B. Rubin, Andrew D. Luster, Xavier Alvarez-Hernandez, Hilary D. Gibson, SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells Development. ,vol. 128, pp. 1971- 1981 ,(2001) , 10.1242/DEV.128.11.1971
J. Wels, R. N. Kaplan, S. Rafii, D. Lyden, Migratory neighbors and distant invaders: tumor-associated niche cells Genes & Development. ,vol. 22, pp. 559- 574 ,(2008) , 10.1101/GAD.1636908
Paula J. Hurley, Fred Bunz, ATM and ATR: components of an integrated circuit. Cell Cycle. ,vol. 6, pp. 414- 417 ,(2007) , 10.4161/CC.6.4.3886
Nagaraj S. Nagathihalli, Ganesh Nagaraju, RAD51 as a potential biomarker and therapeutic target for pancreatic cancer Biochimica et Biophysica Acta. ,vol. 1816, pp. 209- 218 ,(2011) , 10.1016/J.BBCAN.2011.07.004