Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm.

摘要: Background Recent studies have shown that in several countries atopic sensitization to common allergens (common atopy) and symptoms are markedly less prevalent children living on a farm, compared with non-farm the same rural areas. Living conditions farms may, however, vary largely between different countries. It is also not yet known whether ‘protective’ effect of farm environment can be found adults. Materials methods Common atopy respiratory health were assessed by skin prick tests (SPT), questionnaire measurement bronchial hyper-responsiveness (BHR) Sund Stald (SUS) study, cohort study Danish farming students conscripts from areas as controls. Results SPT confirmed IgE serology all SPT+ subjects subset SPT– subjects. Prevalences atopy, hyper- responsiveness for farmers controls, those who had or lived early childhood. Results In multiple logistic regression analyses adjusting ever smoking familial history allergy, both being farmer (ORs 0.62–0.75) having childhood 0.55–0.75) appeared contribute independently lower risk serology. A was inversely associated high total (OR 0.68), presence 0.69–0.79) BHR 0.61) these analyses. Direction strength association varied widely 0.69–1.28). Conclusion The ‘anti-atopy’ protective could students: prevalences positive SPT, specific IgE, allergic born raised farm. Past exposure may therefore disease at later age.