Solid-State Label-Free Integrated Aptasensor Based on Graphene-Mesoporous Silica–Gold Nanoparticle Hybrids and Silver Microspheres
作者： Shaojun Guo , Yan Du , Xuan Yang , Shaojun Dong , Erkang Wang
DOI: 10.1021/AC2019552
关键词:
摘要: Taking advantage of strand-displacement DNA polymerization and parallel-motif triplex system as dual amplifications, a new electrochemical label-free integrated aptasensor based on silver microspheres (SMSs) separation element graphene-mesoporous silica–gold nanoparticle (NP) hybrids (GSGHs) an enhanced the sensing platform was first reported. In this design (schematic representation procedure for adenosine triphosphate detection, Scheme 1 in manuscript text), which contains three-step magnification process, SMSs with “clean” surface were used to separate undesirable aptamer aptamer–adenosine (ATP) complex attached after aptamer–ATP interaction, lead detachment blocker into solution phase. Then, under assistance DNA, amplified method inherent signal-transduction mechanism hairpin probe property polymerase i...
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