Antibiotic sensitivities of coagulase-negative staphylococci and Staphylococcus aureus in hip and knee periprosthetic joint infections: does this differ if patients meet the International Consensus Meeting Criteria?

摘要: Introduction Coagulase-negative staphylococci (CoNS) are the main pathogens responsible for prosthetic joint infections (PJIs). As normal inhabitants of human skin, it is often difficult to define if they contaminants, or have an active role in initiating infection. This study aims evaluate differences CoNS organisms (Staphylococcus hominis, Staphylococcus capitis, haemolyticus, warneri) and aureus terms isolation rate antimicrobial susceptibility from patients who met International Consensus Meeting (ICM) criteria PJIs those did not. Methods Staphylococci isolates January 2014 December 2015 retrieved undergoing revision arthroplasty were classified accordance with established by ICM Philadelphia. Results per consensus classification, 50 39 S. recognized as pathogens, while 16 four considered contaminants. Frequency was significantly higher infected than without infection, no significant observed among CoNS. Resistance levofloxacin, erythromycin, gentamicin trimethoprim/sulfamethoxazole, rifampicin more frequent haemolyticus other species, well resistance erythromycin hominis. In comparison aureus, resistant daptomycin susceptible rifampicin. Conclusion CoNS, epidermidis, frequently isolated PJIs, their infective need be assessed on individual patient basis. seems emerge PJI a large volume patients, its needs further investigated, also considering pattern resistance.