Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure.

作者: Adil Denizli , Menemşe Kiremitçi , Erhan Pişkin

DOI: 10.1016/0142-9612(88)90094-4

关键词:

摘要: The present study was an attempt to design a new polymer-drug composite system for local chemotherapy. Poly(hydroxyethylmethacrylate-bisglycolacrylate) carriers containing anticancer drug, 5-fluorouracil, were prepared by low temperature radiation polymerization technique. By changing the relative amounts and types of ingredients, drug loading dosage, composites with different structural properties obtained. This paper presents preparation procedure analyses some these novel composites.

参考文章(7)
K. Piskin, E. Arca, E. Piskin, Radiopolymerized mixture of acrylic acid, methyl methacrylate, and polyethylene glycol as an enzyme support system Applied Biochemistry and Biotechnology. ,vol. 10, pp. 73- 79 ,(1984) , 10.1007/978-1-4612-5182-8_7
O. WICHTERLE, D. LÍM, Hydrophilic Gels for Biological Use Nature. ,vol. 185, pp. 117- 118 ,(1960) , 10.1038/185117A0
M. F. Refojo, H. Yasuda, Hydrogels from 2-hydroxyethyl methacrylate and propylene glycol monoacrylate Journal of Applied Polymer Science. ,vol. 9, pp. 2425- 2435 ,(1965) , 10.1002/APP.1965.070090707
Pişkin E, Kiremitci M, Properties of new sorbents containing activated carbon-PHEMA-PEG. International Journal of Artificial Organs. ,vol. 8, pp. 201- ,(1985)
Nakamura K, Yamada A, Kaetsu I, Yoshida M, Hanyu F, Sakurai Y, The anticancer drug capsule with controlled-release for a long time and change of release rate. Asaio Journal. ,vol. 26, pp. 514- ,(1980)
K. Piskin, E. Arca, E. Piskin, Radiopolymerized mixture of acrylic acid, methyl methacrylate, and polyethylene glycol as an enzyme support system Applied Biochemistry and Biotechnology. ,vol. 10, pp. 73- 79 ,(1984) , 10.1007/BF02783737