Quick adjustment of imaging tracer payload, for in vivo applications of theranostic nanostructures in the brain

摘要: Abstract In order to provide sufficient sensibility for detection, selection of an adequate payload imaging probe is critical, during the design MRI theranostic nanoplatforms. This fact particularly crucial in vivo applications brain, where delivery macromolecules limited by blood–brain barrier. Here we report a simple and quick process estimation payloads gadolinium liposomes with potential act as agents, brain. Our studies show that excessive may actually have negative influence on T1 contrast. By preparing characterizing 4 different liposomal compositions increasing Gadolinium loads, superior sensitivity detection molecules can be quickly improved adjusting molecules. From Clinical Editor team authors development agents brain studies, using rodent model.