Three-dimensional tissue culture based on magnetic cell levitation
作者： Glauco R. Souza , Jennifer R. Molina , Robert M. Raphael , Michael G. Ozawa , Daniel J. Stark
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摘要: Cell culture is an essential tool in drug discovery, tissue engineering and stem cell research. Conventional tissue culture produces two-dimensional cell growth with gene expression, signalling and morphology that can be different from those found in vivo, and this compromises its clinical relevance,,,,. Here, we report a three-dimensional tissue culture based on magnetic levitation of cells in the presence of a hydrogel consisting of gold, magnetic iron oxide nanoparticles and filamentous bacteriophage. By spatially controlling …
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