Hypoxia and antitumor CD8(+) T cells: An incompatible alliance?
作者： Romain Vuillefroy de Silly , Pierre-Yves Dietrich , Paul R. Walker
DOI: 10.1080/2162402X.2016.1232236
关键词:
摘要: T Lymphocytes face pathologically low O2 tensions within the tumor bed at which they will have to function in order impact on malignancy. Recent studies highlighting importance of and hypoxia-inducible factors for CD8+ T-cell fate must now be integrated into immunology concepts if immunotherapies are progress. Here, we discuss, reinterpret, reconcile many apparent contradictions these data propose that is a master regulator response. Certain cell functions enhanced, others suppressed, but balance, hypoxia globally detrimental antitumor
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