Inhibition of Interleukin-17 Prevents the Development of Arthritis in Vaccinated Mice Challenged with Borrelia burgdorferi

摘要: We showed that Borrelia burgdorferi-vaccinated interferon gamma-deficient (IFN-gamma(0)) mice challenged with the Lyme spirochete developed a prominent chronic severe destructive osteoarthropathy. The immune response underlying development of arthritis involves interleukin-17 (IL-17). Treatment vaccinated IFN-gamma(0) B. burgdorferi anti-IL-17 antibody delayed onset swelling hind paws but, more importantly, inhibited arthritis. Histopathologic examination confirmed treatment prevented arthropathy seen in and mice. Similar preventive results were obtained when treated receptor or sequentially followed by antibody. By contrast, recombinant IL-17 (rIL-17) did not alter progression found without rIL-17. Therapeutic intervention may be realistic approach to prevent arthritis, especially if is involved perpetuation intermittent