Effects of coupled plasma filtration adsorption on immune function of patients with multiple organ dysfunction syndrome.
作者： H.-J. Mao , S. Yu , X.-B. Yu , B. Zhang , L. Zhang
DOI: 10.1177/039139880903200104
关键词:
摘要: ObjectiveTo investigate the effects of coupled plasma filtration adsorption (CPFA) on immune function patients with multiple organ dysfunction syndrome (MODS).MethodsThis study was a prospective, pilot, before-and-after self-crossover, clinical trial. Seven diagnosed MODS and severe infection were randomly allocated to both 10 hours CPFA high-volume hemofiltration (HVHF) 12-hour interval in random order. Serum concentrations 7 cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1Ra), soluble factor receptors 1 2 (sTNFR1 sTNFR2) measured during each treatment. The HLA-DR expression by blood monocytes TNF-α production patients’ (both spontaneous lipopolysaccharide stimulated) tested before after normal human (THP-1 cells) incubated in...
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