EFFECTS OF DIFFERENT GROWTH FACTORS ON NEW BONE FORMATION: A SYSTEMATIC REVIEW
作者： Arash Khojasteh , Mohammad Esmaeelinejad , Navid Naghdi , Hosain Behnia
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摘要: Background and Aim: Using different osteogenic growth factors, which is still under investigation, a favorable method for bone regeneration. This systematic review aimed at evaluating the effects of factors their carriers on osteogenesis. Materials Methods: Electronic databases (Medline, EMBase Cochrane) were searched by authors articles published from 1999 to April 2010. Clinical animal studies formation applying specific factor related carrier included in this investigation. Obtained data organized table evaluated through qualitative analysis. Results: Sixty-three most BMP-2 osteogenesis models study. Totally, twenty-five car riers applied with experiments. Among these riers, poly lactic– co glycolic acid (PLGA), hydroxy apatite/tricalcium phos phate/absorbable collagen sponge (HA/TCP/ACS) BioOss fre quently used regeneration studies. Conclusion: The current evidence, although not strong enough, confirms that has more results compared other factors. scaffold, methods measurement (histologic or radiographic), type animal, defect diameter length follow-up are variables should be matched before reaching definite effect
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