Assessment of research models for testing gene-environment interactions.

摘要: Throughout the last century, possible effects of exposure to toxicants, nutrients or drugs were examined primarily by studies groups populations. Individual variation in responses was acknowledged but could not be analyzed due lack information tools analyze individual genetic make-ups and lifestyle factors such as diet activity. The Human Genome, Haplotype Map, 1000Genomes, Variome Projects are identifying cataloging found within humans. Advances DNA sequencing technologies will soon permit characterization genomes clinical basic research studies, thus allowing associations made between an genotype response a particular exposure. Such knowledge have generated significant challenge for scientists: design conduct that account variation. However, before these done humans, they performed various vivo vitro models. advantages disadvantages some model test systems being used developed relation make-up xenobiotics discussed.