Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation

摘要: Alzheimer's Disease (AD) is the primary cause of dementia among elderly population. Elevated plasma levels homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and biomarker AD other types dementia. An increase in HCy mostly consequence high and/or low vitamin B intake diet. Here, we studied effects physiological pathophysiological concentrations on oxidative stress, synaptic protein levels, activity mice hippocampal slices. We also vitro aggregation kinetics Aβ40. found that cerebrospinal (0.5 µM) induce proteins, whereas higher doses (30-100 decrease their thereby increasing stress causing excitatory transmission hyperactivity, which all to be neurotoxic effects. observed normal slow kinetic Aβ40, accelerate its aggregation. Finally, + Aβ42 over long-term potentiation. Altogether, by studying ample range under different concentrations, report, for first time, can exert beneficial or toxic neurons, evidencing hormetic-like effect. Therefore, further encourage use as modifiable with therapeutic against