The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus.

摘要: Summary Tst, the gene for toxic shock syndrome toxin-1 (TSST1), is part of a 15.2 kb genetic element in Staphylococcus aureus that absent TSST-1-negative strains. The prototype, RN4282, flanked by 17 nucleotide direct repeat and contains genes second possible superantigen toxin, Dichelobacter nodosus VapE homologue putative integrase. It readily transferred to recA π recipient, it always inserts into unique chromosomal copy sequence same orientation. excised circularized staphylococcal phages f13 80a replicates during growth latter, which transduces at very high frequency. Because its site orientation specificity because lacks other identifiable phage-like genes, we consider be pathogenicity island (PI) rather than transposon or defective phage. tst near tyrB, designated SaPI1. That RN3984 trp region only partially homologous SaPI1 phage 80 but not 80a. SaPI2. These PIs are first any Gram-positive species mobility has been demonstrated. Their may responsible spread TSST-1 production among S.