Early disturbances of ambulatory blood pressure load in normotensive type I diabetic patients with microalbuminuria.

摘要: OBJECTIVE To compare 24-h ABP in normotensive type 1 diabetic patients with and without microalbuminuria. RESEARCH DESIGN AND METHODS The study was a retrospective comparison of cases matched control subjects. first phase included 35 patients, by OMS criteria. 23 normoalbuminuria (< 15 μg/min) were compared 12 microalbuminuria (≥ μg/min). In the second phase, microalbuminuric paired sex- age-matched normoalbuminuric nondiabetic healthy We measured casual systolic diastolic BP HR, AHR (recorded Spacelabs automatic recorder), microalbuminuria. RESULTS No correlation between observed. Microalbuminuria correlated significantly APR nocturnal ( r = 0.35, 0.38, 0.33, respectively; P < 0.05) during all time periods (24-h, 0.46; day, 0.39; night, 0.05). Normo- did not differ HR. However, had significant increase (119.1 ± 8.2 vs. 113.1 8.1, 0.05), (74.9 7.5 70.2 5.7, 0.04), (112.8 7.1 105.8 7.9, 0.01), periods. same results observed when age sex. CONCLUSIONS Normotensive although strictly comparable for have an increased especially night. This difference might reflect dysautonomia. Ambulatory measurement HR is more appropriate than measurements hemodynamic studies incipient nephropathies could be proposed as interesting tool early prediction nephropathy.