Rapid Generation of Molecular Complexity in the Lewis or Brønsted Acid-Mediated Reactions of Methylenecyclopropanes

摘要: Although they are highly strained, methylenecyclopropanes (MCPs) readily accessible molecules that have served as useful building blocks in organic synthesis. MCPs can undergo a variety of ring-opening reactions because the release cyclopropyl ring strain (40 kcal/mol) provide thermodynamic driving force for and π-character bonds within cyclopropane afford kinetic opportunity to initiate ring-opening. Since 1970s, chemistry has been widely explored presence transition metal catalysts, but less attention had paid Lewis or Bronsted acid mediated MCPs. During past decade, significant developments also made This Account describes developed our laboratory by other researchers.Lewis acids be used catalysts reagents with substrates, substituents on terminal ...