Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer
作者： Chih-Kuang Chen , Wing-Cheung Law , Ravikumar Aalinkeel , Bindukumar Nair , Atcha Kopwitthaya
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摘要: Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery interleukin-8 (IL-8) siRNA via CPLA-IL-8 nanoplexes. The CPLAs possess remarkable hydrolytic degradability, their cytotoxicity is relatively low. nanoplexes can be readily taken up prostate cancer cells, resulting in significant IL-8 gene silencing. It found that degradability CPLAs, as well transfection efficiency nanoplexes, positively correlate with amine mol% CPLAs.
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