OXIDATIVE DAMAGE TO MITOCHONDRIAL DNA AND ITS RELATIONSHIP TO AGEING

作者: Christoph Richter

DOI: 10.1016/1357-2725(95)00025-K

关键词:

摘要: … to the inner mitochondrial membrane, which produces large amounts of ROS. Therefore, mtDNA is particularly susceptible to oxidative damage. For example, the steady-state level of …

参考文章(37)
M. Calleja, P. Peña, C. Ugalde, C. Ferreiro, R. Marco, R. Garesse, Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. Journal of Biological Chemistry. ,vol. 268, pp. 18891- 18897 ,(1993) , 10.1016/S0021-9258(17)46710-X
W.J. Driggers, S.P. LeDoux, G.L. Wilson, Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. Journal of Biological Chemistry. ,vol. 268, pp. 22042- 22045 ,(1993) , 10.1016/S0021-9258(20)80645-0
N J Gross, G S Getz, M Rabinowitz, Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat Journal of Biological Chemistry. ,vol. 244, pp. 1552- 1562 ,(1969) , 10.1016/S0021-9258(18)91795-3
Youri I. Pavlov, Dana T. Minnick, Shunji Izuta, Thomas A. Kunkel, DNA replication fidelity with 8-oxodeoxyguanosine triphosphate Biochemistry. ,vol. 33, pp. 4695- 4701 ,(1994) , 10.1021/BI00181A029
J. Miquel, A.C. Economos, J. Fleming, J.E. Johnson, Mitochondrial role in cell aging Experimental Gerontology. ,vol. 15, pp. 575- 591 ,(1980) , 10.1016/0531-5565(80)90010-8
Myung H. Chung, Hiroshi Kasai, Susumu Nishimura, Byung P. Yu, Protection of DNA damage by dietary restriction Free Radical Biology and Medicine. ,vol. 12, pp. 523- 525 ,(1992) , 10.1016/0891-5849(92)90105-P
Marisol Corral-Debrinski, Terzah Horton, Marie T. Lott, John M. Shoffner, M. Flint Beal, Douglas C. Wallace, Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genetics. ,vol. 2, pp. 324- 329 ,(1992) , 10.1038/NG1292-324
AnthonyW. Linnane, Takayuki Ozawa, Sangkot Marzuki, Masashi Tanaka, MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES The Lancet. ,vol. 333, pp. 642- 645 ,(1989) , 10.1016/S0140-6736(89)92145-4
C. Münscher, T. Rieger, J. Müller-Höcker, B. Kadenbach, The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Letters. ,vol. 317, pp. 27- 30 ,(1993) , 10.1016/0014-5793(93)81484-H
Kimiko Asano, Shizuko Amagase, Etsuko T. Matsuura, Hideo Yamagishi, Changes in the rat liver mitochondrial DNA upon aging. Mechanisms of Ageing and Development. ,vol. 60, pp. 275- 284 ,(1991) , 10.1016/0047-6374(91)90040-7